N-Heterocyclic-Carbene-Catalyzed Asymmetric Oxidative Hetero-Diels–Alder Reactions with Simple Aliphatic Aldehydes

N-Heterocyclic-Carbene-Catalyzed Asymmetric Oxidative Hetero-Diels–Alder Reactions with Simple Aliphatic Aldehydes:

An efficient enantioselective approach to form trans lactams and cis lactones in up to 98 % yield with greater than 99 % ee, and greater than 20:1 d.r. using simple aliphatic aldehydes has been developed. The process involves a new pathway to generate enolate intermediates from aliphatic aldehydes by oxidation and deprotonation. NHC=N-heterocyclic carbene, Ts=4-toluenesulfonyl.

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